Huntingtons Disease Essay - 1715 Words

Huntington’s disease is a degenerative neurological disorder affecting movement, cognition, and emotional state (Schoenstadt). There are two forms of Huntington’s disease (Sheth). The most common is adult-onset Huntington’s disease, with persons usually developing symptoms in their middle 30s and 40s (Sheth). There is an early onset form of Huntington’s disease, beginning in childhood or adolescence, and makes up a small percentage of the Huntington’s population (Sheth). Huntington’s disease is a genetic disorder with a short history, a plethora of symptoms, and devastating consequences, with no current cure in sight. Cases of Huntington’s disease date back to the early seventeenth century, but those records are basic, with no convincing†¦show more content†¦Every cell within the body contains all of these chromosomes, which have bases arranged to form a code (Appai-Kubi). The four bases, cytosine, adenine, guanine, and thymine, interact to form the fundamental structure of DNA (Appai-Kubi). Huntington’s disease is found on the fourth chromosome and is identified by a sequence known as the â€Å"CAG repeat,† (Appai-Kubi). In someone who is not afflicted, the number of â€Å"CAG repeats,† ranges from 10 to 28 (Sheth). Typically, more than 35 â€Å"CAG repeats,† is associated with Huntington’s disease, however, there are cases with people not afflicted having up to 39 â€Å"CAG repeats,† (Appai-Kubi). The number of repeats generally increases as the gene is passed on through families. An increase number of â€Å"CAG repeats,† generally means earlier development of symptoms (Sheth). ). Huntington’s disease is inherited through an autosomal dominant pattern; meaning that whoever inherits the faulty gene will definitely develop the disease during their lifetime (Genetic Science Learning Center). A parent with the Huntington’s disease mutation has a 50% chance of passing on the gene for the disease to their children (Genetic Science Learning Center). A small number of cases (1 to 3 percent) occur without family history of Huntington’s disease (Schoenstadt). Huntington’s disease can be tested for by looking at the number â€Å"CAG repeats,† on chromosome 4 (Appai-Kubi.) During pregnancy, aShow MoreRelatedEssay on Huntington’s Disease990 Words   |  4 Pagesand mental retardation. (Ridley, 55) Victims of this syndrome rarely live past the age of seven. The last and most interesting situation occurs when this gene becomes mutated. In this case, the individual will suffer from Huntington’s Chorea, a debilitating neurological disease which will not show its effects until mid-life. Because of this disorder, the gene is known as â€Å"The Huntington Gene,† though it has also been referred to as â€Å"The Wolf-Hirschorn Gene† and â€Å"IT15† meaning â€Å"Interesting TranscriptRead MoreHuntington’s Disease Essay787 Words   |  4 Pagesmuch about Huntington’s disease. After reading this paper and the subsequent ones to come, you surely will. According to PudMedHealth.com, à ¢â‚¬Å"Huntington’s disease is a disorder passed down through families in which nerve cells in certain parts of the brain waste away or degenerate.† This can lead to many different complications to a person’s health. In most cases, the disease’s symptoms develop later in life during a person’s mid thirties-forties. There are also instances where the disease becomes on-setRead MoreEssay Huntingtons Disease1113 Words   |  5 PagesHuntingtons Disease Background Huntingtons disease is inherited as an autosomal dominant disease that gives rise to progressive, elective (localized) neural cell death associated with choleric movements (uncontrollable movements of the arms, legs, and face) and dementia. It is one of the more common inherited brain disorders. About 25,000 Americans have it and another 60,000 or so will carry the defective gene and will develop the disorder as they age. Physical deterioration occurs over a periodRead MoreResearch Paper on Huntingtons Disease1268 Words   |  6 PagesHuntington’s disease is a hereditary brain disorder that is progressive in neurodegeneration; which means, there is a loss of function and structures of one’s neurons. In the long run it results in the loss of both mental and physical control. The disease affects muscle coordination, cognition and behavior. It used to be known as Huntington’s chorea because it is the most common genetic disease that is the cause of abnormal twitching. Huntington s has an intense effect on patients, as individualsRead More Understanding Huntingtons Disease Essay1032 Words   |  5 PagesUnderstanding Huntingtons Disease Diagnosis of Huntingtons Disease Today, a blood test is available to diagnose a person displaying suspected Huntingtons symptoms. The test analyzes DNA in the blood sample and counts the number of times the genetic code for the mutated Huntingtons gene is repeated. Individuals with Huntingtons Disease usually have 40 or more such repeats; those without it, 28 or fewer. If the number of repeats falls somewhere in between then more extensive neurologicalRead MoreEssay about Huntingtons Disease1557 Words   |  7 PagesHuntington’s Disease is a brain disorder affecting movement, cognition, and emotions (Schoenstadt). It is a genetic disorder generally affecting people in their middle 30s and 40s (Sheth). Worldwide, Huntington’s disease (affects between 3-7 per 100,000 people of European ancestry (Schoenstadt). In the United States alone, 1 in every 30,000 people has Huntington’s disease (Genetic Learning Center). Huntington’s Disease is a multi-faceted disease, with a complex inheritance p attern and a wide rangeRead MoreEssay about Huntingtons Disease979 Words   |  4 PagesHuntingtons Disease Huntingtons Disease is a genetic autosomal disorder which effects the brain. It affects about 1 in 20,000 individuals. The symptoms of the disease do not start to occur until after or around 40 years of age. With the onset of the disease the patient starts to gradually deteriorate intellectually, this deterioration also causes involuntary movements. Scientists have only recently found the section of the gene which causes Huntingtons disease, and this is allowed themRead MoreTaking a Look at Huntingtons Disease1745 Words   |  7 PagesIntroduction Huntington’s disease is a neurodegenerative disorder that is inherited in an autosomal dominant fashion. The cytoplasmic protein affected in Huntington’s disease is Huntingtin, coded for by the Huntingtin gene. The mutated version of the Huntingtin protein has several degenerative consequences on the molecular level. These are mainly caused by the elongated chain of glutamines that abberantly interacts with proteins and diminishes their biological functions. The mutated protein alsoRead MoreEssay on Huntingtons Disease - An Overview1185 Words   |  5 PagesHuntingtons Disease - An Overview Huntingtons Disease is a devastating and progressive neurological disorder that resu lts primarily from degeneration of nerve cells deep in the center of the brain. The condition was first described by George Huntington, a physician in New York, in 1872. Even then, the physician recognized the all-encompassing factors of the disorder when describing it as, coming on gradually but surely, increasing by degrees, and often occupying years in its developmentRead MoreEssay on Understanding Huntingtons Disease2054 Words   |  9 PagesUnderstanding Huntingtons Disease Huntingtons disease is an inherited neurodegenerative disorder. It is passed on to children from one or both parents (though two parents with Huntingtons is extraordinarily rare) in an autosomal dominant manner. This is different from autosomal recessive disorder, which requires two altered genes (one from each parent) to inherit the disorder. So if one parent has it, and passes the gene on to a child, that child will develop Huntingtons disease if they live

President John F. Kennedy and His Inaugural Address Essay

January 20, 1961 will forever be a day that marks a special moment in time in which President John Fitzgerald Kennedy delivered one of the most memorable speeches in American History. His Inaugural address is one in which many famous quotes come from and one that is emulated in present speeches. In order to understand the importance of this inoculation one must understand the atmosphere of our nation at that time and what President Kennedy was trying to get across to his constituents. In this essay I will give you background information pertaining to the state our union in 1961; discuss the tone of the speech; and finally examine the impact that President Kennedy’s term played on our nation. The year of 1961 saw many highs for Americans†¦show more content†¦Kennedy’s speech was one of inspiration and hope. He wanted to win the confidence of his citizens by delivering a short speech filled with noble ideals (Matheson 11). President Kennedy starts his inaugural address by exclaiming his understanding that America was very different from that of the nation’s predecessors. The President also wanted to send out a warning to all other nations by letting them know that with him as commander-in-chief, America would â€Å"pay any price, bear any burden, meet any hardship, support any friend or oppose any foe in order to assure the survival and success of liberty†(Kennedy 609). Basically he was stating that he would not think twice about using all possible forces in order to preserve peace and prosperity for the United States. He further goes on to offer his support to developing countries by pledging to help them help themselves but with a special st ipulation. He warned these nations to not lean on America’s success but to form their own freedom when he stated, â€Å"remember that, in the past, those who foolishly sought to find power by riding on the tiger’s back inevitably ended up inside† (Kennedy 609). Of all the very remarkable things that this president stated the thing that resonated with me was his backing of the United Nations which would have ultimately dissolved had we not given our support. As stated earlier, our nation was in an atomic war with the Soviet Union and the citizens of the United States wereShow MoreRelatedOn May 29, 1917, Brookline, Massachusetts, Mr. John Frederick806 Words   |  4 PagesBrookline, Massachusetts, Mr. John Frederick Kennedy was born. John F Kennedy was one of nine children born to Joseph and Rose Kennedy(a very wealthy family). His father Joseph Kennedy was a businessman and politician while his mother Rose Kennedy was a philanthropist and socialite. Due to his f amily’s wealth, John F Kennedy s education was more than respectable, attending many private schools since grade school. Once it was time for higher education John F Kennedy briefly attended Princeton UniversityRead MorePublic Service: John F. Kennedys Inaugural Address1219 Words   |  5 PagesPresident John F. Kennedy’s Inaugural Address is considered one of the greatest speeches in history and one of the shortest Inaugural Addresses at just 15 minutes. He attempts to build up America’s pride and calls the nation to support their country. He describes these goals using a variety of rhetorical devices to increase public reaction. His short but powerful speech gives comfort to an American public fearful of war. John Fitzgerald Kennedy was born May 29, 1917, into a new wealthy CatholicRead MoreJohn F. Kennedys Inaugural Address1049 Words   |  5 PagesJohn F. Kennedy’s Inaugural Address Ceremonial speeches are given to mark ceremonial events and help a society move beyond their differences. John F. Kennedy gave a ceremonial speech, his inaugural address, on January 20th, 1961, marking one of the most historic speeches in time. In John F. Kennedy’s Inaugural Address speech, that is being evaluated today, the author uses social cohesion as a call for the nation to give back to the country, as we should do of course, and to ask, and expect lessRead MoreLeslie Cardoso. Leslie Cardoso. Ap English 3. P.3.1082 Words   |  5 PagesCardoso Leslie Cardoso Ap English 3 p.3   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   The JFK Inaugural Address On January 20, 1961, John Fitzgerald Kennedy delivered one of America s few standout inaugural addresses and one of the finest speeches in American history. By invoking the American dream and extending its promise to the rest of the world, Kennedy s speech was an inspirational call to action that resonates even today. John Fitzgerald Kennedy’s Inaugural Address, The article â€Å"Inside Kennedy’s Inauguration, 50 Years on†,Read MoreEssay about John F. Kennedy Analysis704 Words   |  3 PagesMoore JFK Inaugural Address Analysis President John F. Kennedy gave his inaugural address on a January afternoon in 1961. His speech includes many rhetorical devices—included to help convey Kennedy’s subject to his audience. The subject is that human rights are determined by God, rather than the government. Some rhetorical devices Kennedy uses are parallelism, anaphora, and hortative sentences. John F. Kennedy’s use of rhetorical devices within his inaugural address help him convey his message toRead MoreJohn F. Kennedy Inaugural Address1099 Words   |  5 Pagesof our own presidents. It was January 20, 1962 when John Fitzgerald Kennedy took stage to be the thirty-fifth president of the United States. Written by Kennedy in late November of 1960, his inauguration speech goes to explain the various changes of the world as Kennedy campaigned to â€Å"get the country moving again.† His speech begins to address the differences of the generations as he wants to â€Å"pass the torch.† Ke nnedy expresses various ways of getting people together which he bases his entire pointRead MoreCritique of a Public Speech Essay713 Words   |  3 Pages20, 1961 over 49 years ago our late President John F. Kennedy presented the Inaugural Address, in Washington D.C. The weather was very cold, and it was one of the largest crowds at the Inauguration. As I am watching the speech for the very first time, multiple thoughts are coming to my head. Here is our President –Elect presenting this speech to us about how much he is going to help change our county for the better. The beginning first words of his speech immediately grabbed my attentionRead MoreDreams of John F. Kennedy700 Words   |  3 PagesInaugural Address: The Dreams of John F. Kennedy John Fitzgerald Kennedy; even today 50 years after his death, his name still inspires Americans and others around the globe. President Kennedy was elected in 1960; this was the start of a new decade and a new generation and was a time of great change in our nation. Kennedy was the youngest U.S. president in our history and when sworn into office spoke his Inaugural Address. His Inaugural speech addresses many problems faced by Americans and many otherRead MoreThe Inaugural Address Of John F. Kennedy1441 Words   |  6 PagesThe Pathway to Success â€Å"The Inaugural Address of John F. Kennedy is considered one of the greatest speeches in twentieth-century American public address,† says Sara Ann Mehltretter from Penn State University. The 1960s was an important time period during American history. The speech was said to motivate Americans and unite them to successfully create a powerful government. In a time of desperation, the actions that the United States government would take to help come out successful was very importantRead MoreComparing Jfk and Lincolns Inagural Speeches Essay1402 Words   |  6 PagesZachary Soliman Freshman Composition Professor Andrew Worthington 11/26/12 Addressing the Nation Throughout the history of the United States of America, there have been many leaders. President Abraham Lincoln and President John F. Kennedy are arguably two of the greatest presidents that this country has had. Whether it was 1865, during the bloodiest war in the history of the US, or 1961, during the most tense international power struggle that we have ever faced, these men were able to do what

On Turning Ten free essay sample

There are 14 sentences and 32 lines, some of them are long, but others are very short so that the reader will think about these in particularly. There is no rhythm scheme, but there is a cadence which links the single lines. The tone of the poem is sad, due to the word choice which Collins chose â€Å"dark blue speed drained out of it† The color blue is a melancholic color which gives a feeling of sadness and drained is a very ruff and harsh word for a ten year old to use. Billy Collins audience is anyone who is willing to look back into their childhood. It is for people who want to remember their childhood and who lived through the same as Collins did. He lets the audience close into the poem by using imagery which reminds the reader of their own childhood. Such as the blue bike, the tree house, wanting to be a wizard or pirate, these are all memories from many childhoods. We will write a custom essay sample on On Turning Ten or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page Giving examples of all of the different magical and heroic figures that he wanted to be, lets the reader connect because many of the readers have had the same dreams and beliefs as children. Collins starts the poem with stating what he is feeling to let the audience be touched. He uses images like â€Å"reading in bad light† and â€Å"measles† which are things which happen during the childhood and mixes these with words which are developed and don’t really fit into this childhood theme. â€Å"a kind of measles of the spirit† or â€Å"a disfiguring chicken pox of the soul†. Also that he uses images as chickenpox, which usually only happen once in a childhood, can be linked to starting to grow up. If the chicken pox has come, children think that they are turning older and maturing. On one side he is very unhappy that he has to grow up â€Å"its time to say good-bye to my imaginary friends† but on the other hand he seems to be a bit happy about finally growing up â€Å"the beautiful complexity introduced by two†. Just by reading the poem, it seems as if the child has already matured a lot. Because he is thinking about all of these things, whereas he could just be playing with friends. But he is sitting in bed and thinking about something very important to him. But I can lie on my bad and remember every digit† He does things which are actually very grown up, like â€Å"But now I am mostly at the window watching the late afternoon light†. He does not need to change anything anymore because the way that he acts he is already very mature, that is one of the messages that the author wants to bring in this poem. Collins wants to say with this poem that it i s hard leaving the childhood behind and starting to mature. However since he was not turning ten years old as he was writing this poem, there is a certain irony to it. It shows that even at any age it is possible to feel like having to leave the childhood behind. Or an aspect of life, because there is more responsibility which to be taken, when having a family for example. This poem deals with the realities of growing up, as he refers to turning ten as a disease, similar to chicken pox, because sooner or later, we all get it. We all must grow up, leave our simple and happy lives behind and accept the real world and its burdens that follow coming of age. . The last line of this poem alludes to Shelleys Ode to the West Wind and in the poem Collins is mocking Shelley. It is not about the complexity of becoming older but saying that Shelley was not old enough to look back it is just as insane as a 10 year old looking back on their life when the majority want to be older. This poem shows the reality of becoming older. it is not as exciting as it may seem because it is quite depressing to think that you cannot be a child anymore. not only do others expect more of you because you are now mature, but you expect more of yourself too. it is no longer okay to have an imaginary friend when you are ten. h no, that is no longer cool. in addition your imagination starts to escape you and you no longer find the fun it playing with action heroes or Barbie and Ken. soon enough people expect you to have a boyfriend or girlfriend (youre eleven years old!!! )and you start to give into peer pressure. now you hardly recognize your childhood. it is gone from your grasp and can no longer be retrieved from the depths of your soul. Billy Collins truly portrays this sadness and great loss terrifically with his amazing poetic abilities. st Stanza references to sickness. negative connotations 2nd Stanza -2nd 3rd lines = nostalgic yearning last four lines = humourous childlike dreams and images 3rd Stanza -more serious tine contrasts with previous stanza 4th stanza -repitition of time Conclusion -makes reader reflect on own life and childhood -ironic mature tone. strange for a child to think this way -gives new perspective on aging and how old is old -aging has nothing to do with age, more the extent of the general outlook on life.

Riordan Forecasting free essay sample

Riordan Manufacturing has a reputation for preciseness and conception. It necessary for Riordan to develop a forecasting process that streamlines production and minimizes unsold inventory. Forecasts are vital to every business organization and for every significant management decision, (Chase, Jacobs, Aquilano, 2006). The process of forecasting is necessary not only for inventory and production, but also for budgetary and financial purposes as well. Without sufficient information to allow for lean production and maximization of profit, Riordan will continue to operate inefficiently and may eventually go out of business. Coordination between sales, marketing, and production and development will be required as part of the new production process. To accomplish this, Riordan will use several different forecasting methods to analyze their data and inventory. One such process is time series analysis. This type of forecasting will allow Riordan to scrutinize past data to project what products will necessary for future sales. Riordan will also use casual forecasting which means the company will assume that the demand for their products are based off of underlying environmental factors. We will write a custom essay sample on Riordan Forecasting or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page Environmental or seasonal factors greatly effect the demand for Riordan’s product. A seasonal factor is the amount of correction needed in a time series to adjust for the season of the year, (Chase, Jacobs, Aquilano, 2006). Since the product is fans, it is acceptable to assume that demand for the product will increase seasonal by region. Hotter temperatures will warrant higher demand for the product and an increase in the sellable inventory and production speed. Cooler temperatures will create less demand and require less inventory and decreased production. As the world moves into green technology, Riordan will also be required to re-develop their product to be more energy efficient and therefore more desirable to the consumers. Riordan will use multiplicative seasonal variation to accurately forecast the need for the fans during seasonal transitions. In this case, the forecast will equal trend times seasonal factor. The first step in forecasting Riordan’s product needs begin at the grass roots level or the bottom tier of the company. This will require warehouse orkers to inventory parts, supplies, and fully assembled product in order to determine exactly what the company has on hand. This information will be carried forward to each level of the company until eventually the top tier of the company is reached. It is also recommended that Riordan hire an outside research company that specializes in market research in order to assist Riordan with their forecasting. Customers, clients, and vendors will be surveyed for feedback on the product. Employees will also be asked for feedback and input on the product. Employees will also be encouraged to share ideas to streamline the assembly process, reach the consumer faster with the product, and assist with the development of new product lines. It is important for Riordan to understand any residual errors in forecasting. Residuals occur when there are variances between the forecast and the actual results. Confidence limits will be established to allow Riordan to measure their forecasts and continue to accurately predict the future sales of the company.